TTN and cerebral palsy: In fascioscapulohumeral muscular dystrophy (FSHD) titin-based stiffness is increased (Lassche et al., 2013) and in cerebral palsy patients, an increase in titin-based passive stiffness has been implicated as well (Ottenheijm and Granzier, 2010; Fridén and Lieber, 2003).