The tumor suppressor geneTP53 encodes for protein P53 and is the most frequently mutated gene in human cancer.10 Emerging data suggest that a mutant protein P53 (P53mt) is associated with genomic instability, aberrant cell cycling, invasion, metastasis, and drug resistance.10, 11 It is known that P53 mutation occurs in almost all HGSOC (96%).11 Kuhn et al13 additionally reported that missense mutations of TP53 were observed in 61% of serous tubal intraepithelial carcinomas (STIC), which is regarded as the precursor of HGSOC. The gene discussed is TP53; the disease is cancer.