Importantly, RD‐N significantly increased cisplatin cytotoxicity, because lysosomal transporters are shown to mediate cellular resistance to cisplatin.32 Despite the substantial investigations performed on CTSB, little is known about the mechanisms by which this protein promotes caspase‐independent apoptosis.33 CTSB may play two opposing roles in malignancy: as an executioner of apoptosis in cytotoxic signalling cascades and a mediator of tumour invasion.34, 35 In this study, we provided a novel mechanism for the pro‐apoptotic action of CTSB. This evidence concerns the gene CTSB and neoplasm.