They also pointed out the role of the mitogen‐activated protein kinase (MAPK) signalling pathways played in the activity of AP‐1 factors.19 Now, c‐Jun has been proved to have a regulation on proliferation, apoptosis, tumorigenesis and many other cell activities in various cancers.20, 21 Previous study figured that c‐Jun mostly was a positive regulator in cell proliferation.22 Our findings were same as above. The gene discussed is JUN; the disease is cancer.