The previous finding that FAM3B‐258 mediates the down‐regulation of E‐cadherin in colorectal cancer cell migration and invasion prompted our interest in examining whether FAM3B also has a similar effect on E‐cadherin in ECA109 cells and whether Snail, a key regulator of E‐cadherin, is also regulated by FAM3B. The gene discussed is CDH1; the disease is colorectal cancer.