Since then, the regulatory role of FAM3B in the progression of other tumours, including oral squamous cell carcinoma and colon and prostate cancer, have been reported.18, 19, 20 In addition, another FAM3 family member, FAM3C, was reported to be closely involved in the development of oesophageal cancer.21 These studies have increased interest in exploring whether FAM3B also plays an important role in the progression of oesophageal cancer. This evidence concerns the gene FAM3B and oral cavity squamous cell carcinoma.