By contrast, Kim et  al previously reported that overexpression of FAM3B leads to the inhibition of tumour growth and reduction of the single‐cell colony‐forming activity and tumorigenicity of gastric cancer cells.23 Shiiba et  al18 recently reported that FAM3B expression in oral squamous cell carcinoma is significantly down‐regulated compared with normal oral tissues. Here, FAM3B is linked to oral cavity squamous cell carcinoma.