NFKB1 and colitis: MALT1 activity is required not only for the immune response, but also for the development of natural Treg cells that keep the immune response in check and is an essential regulator for NF‐κB activation.138 Its inhibition attenuated symptoms of dextran sodium sulfate‐induced colitis in mice reducing activation of NF‐κB and NLRP3 inflammasome in macrophages.139 MALT1‐deficient patients fail to generate memory and Treg cells and develop hypogammaglobulinemia, due to impaired NF‐κB signaling in lymphocytes resulting in immune dysregulation.