For instance, hematopoetic stem cell transplantation is currently the only curative therapy for patients with IL‐10R deficiency26 and has been shown to result in a positive clinical outcome in some patients with LRBA deficiency.180 Treatment of CTLA‐4 haploinsufficiency and LRBA are prime examples of genome‐informed precision medicine, where treatment with Abatacept (CTLA‐4‐Ig) has proved to be successful in alleviating the infiltrative and autoimmune disease.125, 181. The gene discussed is CTLA4; the disease is autoimmune disease.