To date, studies on the prognostic role of the density of CD3+ and CD8+ lymphocytes in the central- and peri-tumoral areas represented by intensity of IHC staining have gained increased attention [4, 27, 28], and this method has been validated through both a single-centre cohort study [5] and international multi-centre validation in localized colon cancer [6]. This evidence concerns the gene CD8A and colonic neoplasm.