A summary of the immune cell composition within and across clinical subgroups of colon cancer tissues further showed that plasma cells, M2 macrophages, CD4+ resting memory T cells, M0 macrophages, and activated mast cells were the five most common immune cell fractions, and the sum of their mean proportions was more than 60% in all clinical subgroups (Supplemental Fig. 2). This evidence concerns the gene CD4 and malignant colon neoplasm.