One previous study found that miR-21 levels in cerebrospinal fluid exosomes of GBM patients were upregulated ten-fold compared to controls,7 while another reported that serum exosomal miR-320, miR-547-3p, and RNU6-1 were significantly associated with GBM diagnosis, as well as outcome (RNU6-1).8 However, to date no comprehensive analysis of the entire miRNA repertoire of serum exosomes in glioma patients has been performed. Here, RNU6-1 is linked to glioblastoma.