A study revealed that T cells isolated from cervical cancer patients co-cultured with recombinant B7-H4 for 48 h, which resulted activated T cell arrest at the G1/G2 phase,29 another experiment with co-cultured cytotoxic lymphocytes with Lewis lung carcinoma cell line showed that membrane bound B7-H4-induced CTL apoptosis which was partially reversed when B7-H4 blocked with a neutralizing monoclonal antibody.30 Decreased TILs in the tumor microenviroment decreases production of pro-inflammatory cytokines such as IFN-γ. This evidence concerns the gene IFNG and neoplasm.