The AKT arm of this pathway is consistent with what has been described in glioma stem cells and Drosophila neuroblasts, whereby Notch1 associates with PTEN-induced kinase 1 (PINK1) on the mitochondrial surface to modulate mitochondrial function, and activates mTORC2/AKT signaling (31). This evidence concerns the gene NOTCH1 and central nervous system cancer.