As previously discussed, whole genome arrays identified three other distinct DLBCL subsets: the oxidative phosphorylation (OxPhos) cluster, which is significantly enriched in genes involved in mitochondrial metabolism; the B cell receptor (BCR) signature, characterized by an up-regulation of cell-cycle regulatory genes and BCR components, later associated with glycolytic metabolism; and the Host Response (HR) cluster displaying components of the T-cell receptor and of molecules implicated in T/NK cell activation (38, 39). Here, BCR is linked to diffuse large B-cell lymphoma.