MTOR and neoplasm: Here, we focus on tumor intrinsic factors leading to aberrant mTORC1 signaling in the three most common types of NH B-cell lymphomas, the high-grade MCL and DLBCL and the low-grade FL, and describe preclinical and clinical studies evaluating rapalogs (mTOR inhibitors) in the treatment of refactory/relapsed MCL, DLBCL and FL (Table 1).