Mice null for Pdcd6ip develop hydrocephalus resulting in bilateral enlargement of the lateral ventricles, thinning of the cerebral cortex and atrophy of the hippocampus.28 The loss of Pdcd6ip caused disorganisation of alignment of cilia and a loss of integrity of epithelial cell barriers in the brain and other tissues.28 These mouse data combined with our observations from zebrafish strongly implicate PDCD6IP as a disease locus in neurodevelopmental disorders. The gene discussed is PDCD6IP; the disease is Hydrocephalus.