HIF1A and Parkinson disease: The largest module (labeled as M1) contained pathways related to the processes of endocytosis and vesicle transport, both of which are putatively disrupted in PD.31 M2 comprised pathways related to PTK6 signaling such as the Reactome pathway, PTK6 promotes HIF1A stabilization, whose high pathway enrichment significance (q-value = 0.0005), as well as its role in regulating another PDgset gene, ATP13A2,32 suggests that it may be linked to PD.