PRB4 and infection: In line with the notion of a trade‐off between immunity and immunity‐induced damage, work in the mealworm beetle shows that deployment of the immune effector phenoloxidase (PO) causes early‐life inflammation, faster aging, and immunopathology at old age, whereas RNAi silencing of PO extends lifespan and improves survival after infection (Khan et al.2017).