Hadlock et al. [50] noted elevated immune response to HERV-K(HML-2) Gag protein in serum samples from ALS patients, and recently it was shown that overexpression of the HERV-K(HML-2) envelope protein causes motor neuron toxicity and motor dysfunction in transgenic mice [51]. The gene discussed is CLEC10A; the disease is amyotrophic lateral sclerosis.