In addition to positively improving glycaemic control, many of the ‘newer’ diabetes therapies (i.e., SGLT2i, GLP1-RA, DPP4i) have extra-glycaemic benefits, such as reduction in LDL-c, improvements in HDL-c, stabilisation of endothelial cells, reduction in inflammation, regulating adipokine release with the added benefits of weight loss [20]. This evidence concerns the gene GLP1R and diabetes mellitus.