ACTA1 and gonorrhea: Another gonorrhea vaccine candidate we investigated in our PM study was NGO1344, which contains an AsmA domain (Figure 3L) and is homologous to the AsmA protein from E. coli and Nm. In E. coli, loss of AsmA decreased LPS synthesis (177); however, a similar phenotype was not observed in a Nm ΔasmA mutant (178).