Although Tim-3 expression on the splenic Tc cells in the RH group remained higher than that of the ME49 group at day 7 post-infection, it was not significant (Figures 2C,D, RH group vs. ME49 group: 6.00 ± 0.52 vs. 4.97 ± 0.40, P > 0.05). The gene discussed is HAVCR2; the disease is infection.