Splenic CD3+CD8+ Tc cells from the RH group had higher Tim-3 expression compared to that of the ME49 group post-infection (Figures 1C,D, RH group vs. ME49 group: day 3, 3.20 ± 0.10 vs. 1.07 ± 0.32, P < 0.001; day 5, 2.80 ± 0.17 vs. 1.73 ± 0.12, P < 0.001; day 7, 4.47 ± 0.50 vs. 3.23 ± 0.12, P < 0.05; day 9, 5.70 ± 0.50 vs. 2.13 ± 0.25, P < 0.001). Here, HAVCR2 is linked to infection.