The circulatory Th cells in the RH group had significantly higher Tim-3 expression compared to that of the ME49 group at day 5 and 9 post-infection (Figures 2A,B, RH group vs. ME49 group: day 5, 4.77 ± 0.76 vs. 2.93 ± 0.76, P < 0.05; day 9, 3.67 ± 0.45 vs. 2.20 ± 0.17, P < 0.01). Here, HAVCR2 is linked to infection.