HAVCR2 and infection: Although Tim-3 expression on splenic Th cells in the RH group remained higher than that of the ME49 group at day 7 post-infection, it was not significant (Figures 2A,B, RH group vs. ME49 group: 3.77 ± 0.81 vs. 3.23 ± 0.32, P > 0.05).