TLRs are expressed in both resident CNS glia and infiltrating immune cells, and an increase in TLR2 expression has been observed in MS demyelinating brain lesions, where the TLR1/TLR2 and TLR6/TLR2 heterodimers recognize tri- or diacyl lipopeptides from bacteria, respectively (Sloane et al., 2010). Here, TLR6 is linked to myeloid sarcoma.