In GN-CS group, the uninterrupted increase in TNF-α and IFN-expression may have compromised the epithelial barrier and thus facilitated the translocation of the S. Typhimurium to liver and spleen, contrarily to the GN-PS group where the decrease in the expression of TNF-α and IFN-γ may be associated with improved preservation of intestinal epithelial integrity and resistance to translocation of the pathogen, which were observed in the administration of L. diolivorans 1Z. Here, IFNA1 is linked to ganglioneuroma.