In the liver, there was a progressive increase in the expression of the cytokines IFN-γ, TNF-α and IL-1β, TGF-β, IL-10, and enzyme iNOS in the GN-PS and GN-CS groups until day 6, followed by a tendency to a decrease in the expression of hepatic TNF-α, IL1-β, and iNOS in PS group when compared with the GN-CS group. Here, IL1B is linked to ganglioneuroma.