The authors identified four significantly hypomethylated CpGs in the first exon of TLR4 in obese individuals compared to healthy controls, while methylation of seven CpGs in the promoter region of TLR2 was significantly lower in subjects with T2D compared to obese subjects and normal-weight controls, which correlated with body mass index (BMI) (52). Here, TLR4 is linked to type 2 diabetes mellitus.