INS and type 2 diabetes mellitus: Furthermore, these identified hypermethylated regions mapped to pathways related to T2D, including cell surface signaling, glucose transport, insulin signaling, pancreas development, and the immune system, whereas hypomethylated regions related to the pro-inflammatory NF-κB cascade, as well as metabolism pathways for polyunsaturated omega-6 fatty acids, linoleic acid, and arachidonic acid (90).