The loci identified by the Chambers study were later evaluated in an independent cohort (the Botnia prospective study) by Dayeh et al. (81), who confirmed an association between ABCG1 and PHOSPHO1 methylation in whole blood and future T2D risk but not SOCS3, SREBF1, or TXNIP. They found that ABCG1 hypermethylation positively associated with HbA1c and fasting insulin levels. The gene discussed is SOCS3; the disease is type 2 diabetes mellitus.