This is in line with expression studies performed by Szabat et al. (100), who demonstrated that MSI2 could be upregulated in response to lipotoxicity and endoplasmic reticulum (ER) stress, and that knockdown/overexpression of MSI2 in mouse pancreatic beta cells resulted in significantly altered insulin expression, suggesting a potential modulatory role for MSI2 in T2D. This evidence concerns the gene INS and type 2 diabetes mellitus.