SOCS3 and type 2 diabetes mellitus: Differentially methylated CpG sites were identified within 853 genes in individuals with T2D, including known T2D-associated loci, TCF7L2, FTO, and KCNQ1. The authors also found that CpG sites in thioredoxin-interacting protein (TXNIP), ATP-binding cassette sub-family G member 1 (ABCG1), phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), suppressor of cytokine signaling 3 (SOCS3), and sterol regulatory element-binding transcription factor 1 (SREBF1) were significantly associated with the future development of T2D (80).