The most significant methylation differences between T2D and control subjects mapped to the SLC30A8, TCF7L2, FTO, potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), thyroid adenoma associated protein (THADA), and juxtaposed with another zinc finger protein 1 (JAZF1) genes (79). The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.