ADCYAP1 and Hypoglycemia: Reflex stimulation of the splanchnic nerve after hypoglycemia induced by insulin shock increased plasma epinephrine levels, and adrenomedullary TH activity: both effects were blunted or abolished in PACAP-deficient mice, and correction of hypoglycemia did not occur, a fatal outcome unless prevented by intraperitoneal injection of PACAP or glucose itself (28).