LPS-activated microglia release cytokines, including TNF-alpha, IL-1 alpha, and C1q, that have been associated with autoimmune inflammation, an association that led to the development of vaccines, including anti-TNF-alpha antibodies (for the treatment of autoimmune disorders) and anti-C1q antibody, currently in phase I trials for both AD and autoimmunity (10, 11). The gene discussed is TNF; the disease is Alzheimer disease.