NLRP3 and atrial fibrillation: In addition, a Cardiomyocyte (CM)-specific knock-in a murine model (CKI, expressing functional NLRP3 inflammasome in CMs only) developed 100% premature atrial contractions with significantly increased inducible AF, whereas a selective inflammasome inhibitor MCC950 could successfully decrease the inducible AF in CKI mice (Yao et al., 2018), recognizing the NLRP3 inflammasome as a new promotor of fibrogenesis and AF.