Possible mechanisms of ASR and connexins remodeling in CKD should include the TGFβ1/Smad2/3 signaling, NLRP3 inflammasome/caspase-1/IL-1β and IL18 axis, and the changes of Rac-1, CTGF and N-cadherin. The gene discussed is TGFB1; the disease is chronic kidney disease.