The renin-angiotensin system also stimulates NADPH oxidase activity contributing to oxidative stress, endothelial dysfunction, and structural vascular changes typical of hypertension and atherosclerosis (Dzau, 1987; Heart Outcomes Prevention Evaluation Study Investigators et al., 2000; Guzik and Touyz, 2017). This evidence concerns the gene FMO5 and atherosclerosis.