FMO5 and obesity due to melanocortin 4 receptor deficiency: In pathologic conditions such as obesity and atherosclerosis, PVAT changes its phenotype and can contribute to vascular oxidative stress because they have an increment in NADPH oxidases in adipocytes with increase activity in obesity-related conditions (Gao et al., 2006; Gil-Ortega et al., 2014; Padilla et al., 2015).