Consequently, 15 targets were overlapped, including MMP1, CASP3AKT1, HIF1A, IL10, MMP9, PTGS2, BCL2, BAX,MMP2, PTGS1, SLC6A2, PRKCA, LGALS3, BCHE, which were predicted as the candidate targets for SAL in treatment DKD. This evidence concerns the gene MMP2 and diabetic kidney disease.