Consequently, 15 targets were overlapped, including MMP1, CASP3AKT1, HIF1A, IL10, MMP9, PTGS2, BCL2, BAX,MMP2, PTGS1, SLC6A2, PRKCA, LGALS3, BCHE, which were predicted as the candidate targets for SAL in treatment DKD. The gene discussed is PTGS2; the disease is diabetic kidney disease.