PSTPIP2 has been known for its principal role in the development of inflammatory disorder described as chronic multifocal osteomyelitis in mice, where its reduced expression or complete absence is the main cause of the disease (Ferguson et al., 2006; Grosse et al., 2006; Chitu et al., 2009; Gurung et al., 2016). Here, PSTPIP2 is linked to chronic recurrent multifocal osteomyelitis.