Nanoparticles encapsulation based on chitosan, polymer micelles, liposome, and serum albumin improved the stability and in vitro biocompatibility of RES (Lu et al., 2009, 2013; Liu et al., 2015; Fan et al., 2018; Jhaveri et al., 2018; Trotta et al., 2018), which is beneficial for biomedical applications in protection against ultraviolet radiation, radiological injury, β-amyloid disease, and tumor (Lu et al., 2009; Yin et al., 2014; Doppalapudi and Mahira, 2017; Jhaveri et al., 2018). The gene discussed is ALB; the disease is neoplasm.