JAK3 and T-cell acute lymphoblastic leukemia: JAK1 has been implicated with different kinds of acute leukemia or B-cell lymphoma dependent on mutated sites, JAK2 mutation was usually associated with thrombocytosis, myelofibrosis, leukemia, and lymphoma and increased JAK3 signaling can result in T-cell acute lymphocytic leukemia (O’Shea et al., 2013; Zhang et al., 2018).