Furthermore, in another study by Borrello et al. (2005), it was reported that transforming oncogene RET/PTC1 in human papillary thyroid carcinoma can induce the expression of CXCL12 and its receptor CXCR4, thus triggering autocrine proliferation of thyroid carcinoma cells (Borrello et al., 2005). This evidence concerns the gene CXCL12 and differentiated thyroid carcinoma.