CAMK2A and memory impairment: KI transgenic mice that express a form of CaMKIIα lacking its kinase activity showed learning and consequent memory impairment in a one-trial inhibitory avoidance task, while KI animals with impaired autophosphorylation at T286 had learning and memory impairments in one-trial passive avoidance tasks, the water Morris maze and contextual fear conditioning (Giese et al., 1998; Irvine et al., 2005; Yamagata et al., 2009).