SIRT1 and ischemia: Compared with the wild-type mice, SIRT1-knockout mice had larger infarct volumes following permanent focal ischemia (Hernández-Jiménez et al., 2013), and in contrast, mice with SIRT1 overexpression showed less hippocampal damage after bilateral common carotid artery occlusion (BCAO) (Hellberg et al., 2010).