MAPT and Alzheimer disease: In human AD brains, tangle bearing neurons have been shown to demonstrate increased immunoreactivity for lipid rafts associated proteins derived from lysosomes, PC levels have also been observed in purified paired helical filaments, and given the involvement of tau in transport of vesicles along microtubule tracks, suggests their role in altered subcellular vesicular transport of lipids (Girardot et al., 2003; Gellermann et al., 2006).