However, mTOR hyperactivity is closely associated with the presence of two hallmarks of AD (Aβ plaques and NFT) and cognitive deficits in clinical presentation (Cai et al., 2012[14]; Lafay-Chebassier et al., 2005[41]; Pozueta et al., 2013[60]). The gene discussed is MTOR; the disease is Alzheimer disease.