In line with our finding, previous studies also showed increased AChE activity and concurrent memory impairments in STZ-induced AD rats (Agrawal et al., 2009[2]; Gutierres et al., 2014[28]; Saxena et al., 2008[70]; Sharma et al., 2012[72]; Tiwari et al., 2009[81]). This evidence concerns the gene ACHE and memory impairment.