CREB1 and Alzheimer disease: It has been revealed that autophagy may be a part of pro-survival (PI3K/Akt/ mTOR/CREB) signaling, and the activation of autophagy results in the restoration of oxidative defense mechanisms and neuronal damages as well as conserving the integrity of synapse and neurotransmission in the rat model of AD (Singh et al., 2017[74]).