Several signaling pathways have been shown to be critical players in HCC such as the Wnt/β Catenin (Herbst and Kolligs, 2007[30]), p53 (Hsu et al., 1993[32]), Ras (Liao et al., 1997[60]) and JAK/STAT pathway (Wormald and Hilton, 2004[102]). This evidence concerns the gene TP53 and hepatocellular carcinoma.