Hou et al. (2017[31]) demonstrated that hepatitis B virus X protein (HBx) could upregulate the long non-coding RNA MALAT-1 in HCC, and MALAT-1 could further influence the expression of latent transforming growth factor β-binding protein 3 (LTBP3), resulting in further progress and metastasis of HCC. Here, MALAT1 is linked to hepatocellular carcinoma.