Wang et al. (2015[94]) demonstrated that UCA1 may act as an endogenous sponge by directly binding to miR-216b, and downregulation of miR-216b expression results in repression of fibroblast growth factor receptor1 (FGFR1) expression and activation of an FGFR1/ERK signaling pathway in HCC. This evidence concerns the gene FGFR1 and hepatocellular carcinoma.