Our observation that the TRPS1-CHD4/NuRD(MTA2) complex transcriptionally represses TP63 via involving decommission of TP63 enhancer and leading to a reduction of ΔNp63 provided additional mechanistic insight into the transcriptional regulation of TP63. Thus the TPRS1-CHD4/NuRD(MTA2) complex is upstream of ΔNp63, which is the main isoform in breast cancer. Here, MTA2 is linked to breast cancer.