MAPT and major depressive disorder: To test this, we examined whether higher levels of tau pathology in the entorhinal cortex (EC) and/or inferior temporal cortex (IT), determined by Flortaucipir (FTP)-PET, were associated with greater loneliness after adjusting for age, sex, APOEε4 status, socioeconomic status, social network, depression, anxiety, and memory function within this CN sample.