In a subsequent study, investigating the less elucidated transcriptional regulation of mutant p53 however, it could be determined that either ectopic expression of HDAC8 or the use of the inhibitors SAHA or sodium butyrate (NaB) increases mutant transcript and protein expression levels of p53 via modulating the HoxA5 transcription factor in tumor cells [160]. This evidence concerns the gene TP53 and neoplasm.