Previous reports indicate that EriB can induce leukemia and lymphoma cell apoptosis by increasing intracellular ROS levels and inhibiting NF-κB pathway, previous studies have also confirmed that EriB can block TNF-induced NF-κB activation by inhibiting IκB degradation in acute myeloid leukemia cell line Kasumi-1 cells. The gene discussed is NFKB1; the disease is leukemia.