MATR3 and amyotrophic lateral sclerosis: Subsequent to the identification of ALS-linked MATR3 mutations, Johnson and colleagues reclassified the original VCPDM S85C cases as ALS [7]; however, there have now been additional families with the S85C mutation that have been diagnosed with VCPDM, without indication of ALS [2, 12, 13, 19, 26], highlighting our lack of understanding of which disease(s) MATR3 mutations cause.