TARDBP and amyotrophic lateral sclerosis: Since the late 2000s, there have been over a dozen genes in which mutations have been identified as causative for ALS, including Tar DNA binding protein (TARDBP) [21, 27], fused in sarcoma (FUS) [10, 22], and the GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) [4, 16], with matrin 3 (MATR3) being one of the more recently discovered genes to have disease causing mutations [7].