These results demonstrated that both OX40 agonist and PD-1 blocking antibodies led to increased CD107a degranulation in CD8+ T cells (Fig. 6b) compared to the IgG control, which was followed by cleavage of caspases 3 and 7 in the B16.F10-ova tumor cells (Fig. 6c) and DNA fragmentation (Fig. 6d) as compared to both the ‘no T cell’ and unstimulated controls. Here, TNFRSF4 is linked to neoplasm.