To examine whether there were age-dependent differences in the composition of the total CD4+ T-helper cell pool with total CD4+CD127low+/–FoxP3+ regulatory T cells (Tregs) and CD4+CD127+FoxP3− responder T cells (Tresps), we estimated the percentages of both T-cell subsets in 78 SLE patients and 94 healthy controls of various ages. This evidence concerns the gene FOXP3 and systemic lupus erythematosus.