HLA-DQB1 and chronic hepatitis B virus infection: Moreover, a previous meta-analysis [16] has indicated that some HLA-DQB1 polymorphisms (HLA-DQB1*02:01, HLA-DQB1*03:01, and HLA-DQB1*05:02) are associated with susceptibility to chronic hepatitis B (CHB), while decreased susceptibility to CHB was observed for HLA-DQB1*03:03 and HLA-DQB1*06:04.