A previous study [29] also detected elevated HLA-DQB1 mRNA expression in cases with HLA-DQB1*06:02, which was associated with narcolepsy, We also found that the risk allele DQB1*05:03 have significantly lower IFN-γ and IL-4 levels compared than protect allele DQB1*05:01, at the same time, the immune negative regulatory factor IL-10 have no difference between risk alleles and protect alleles in HBV group. This evidence concerns the gene IL4 and narcolepsy.