Furthermore, adipocyte-derived adipokines activate cell surface receptors and drive signaling through the Janus kinase (JAK)/signal transducers and activators of transcription (STAT), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) signaling pathways, all of which are frequently altered in cancer [7]. The gene discussed is WNK2; the disease is cancer.