Of note, siRNA treatment did not affect genetic levels of N-cad (Fig. 1c) but the combination of ER stressors (i.e., drug treatments) and siRNA transfection did induce significant downregulation in N-cad mRNA levels, suggesting that ER stressors (such as that induced by BTZ) may sensitize MM cells to siRNA treatment. Here, CDH2 is linked to Miyoshi myopathy.