As expected, markers of normal colonocytes, such as Solute Carrier Family 26 Member 3 (SLC26A3) [18, 19], Chloride Channel Accessory 4 (CLCA4) and Membrane Spanning 4-Domains A12 (MS4A12) [20, 21], as well as other enterocyte markers such as Carcinoembryonic Antigen Related Cell Adhesion Molecule 7 (CEACAM7) [22], Guanylate Cyclase Activator 2A (GUCA2A) [23], Aquaporin 8 (AQP8) [24], isoforms CA1, CA2, CA4 of Carbonic Anhydrase and Keratin 20 (KRT20) [25, 26] were downregulated in the three CRC groups. The gene discussed is CA4; the disease is colorectal carcinoma.