In conclusion, the LB and MSI groups appear to be characterized by specific genes involved in secretory processes, colon mucus barrier, and mucosal protection, whereas HB tumors show overexpression of a subset of genes typical for surface colonocytes, along with EGF signaling agonists AREG and EREG, whose upregulation might be of predictive relevance for therapeutic choices. Here, EREG is linked to hemoglobin measurement.