In K562, the transcription factor E2F6, which might function as a repressor, is enriched in K562 single enhancers, while transcription factors STAT5, TAL1 and GATA2, which are all associated with growing culture and differentiation of leukemia cell, are significantly enriched in redundant enhancers [52–55] (Additional file 1: Figure S2A). Here, E2F6 is linked to leukemia.