Clinical neuropathy and cognitive deficits are associated with CGL2 and mutations in seipin (BSCL2), and are rare but not unknown for CGL3 and CGL4 syndromes [associated with caveolin-1 (CAV1) and cavin (RNA polymerase 1 and transcript release factor: PTRF) gene mutations, respectively] (1,2). Here, CAV1 is linked to Cognitive impairment.