PDGFC and neoplasm: PDGF-C was shown to be a target of HIF-1α-mediated transcriptional activation [63], and small changes in HIF-1α expression which are not readily detected by Western Blot analyses could still be involved in the up-regulation of PDGF-C in PHD3-deficient LM8 cells and tumors, especially if one takes into account that tumor hypoxia was increased (Supplementary Figure S6).