Viguiliouk et al. 2014 [3] focused on subjects with T2DM in a meta-analysis of 12 RCTs (n = 450) of ≥3 weeks duration to investigate the effects of tree nut consumption on glycemic control (glycosylated hemoglobin (HbA1c), fasting glucose, fasting insulin and homeostasis model assessment of insulin resistance index (HOMA-IR)) compared with isocaloric diets without tree nuts. This evidence concerns the gene INS and Insulin resistance.